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We know that immune dysregulation is implicated in a range of diseases, from diabetes to neurodegeneration. And we know that the brain is a principal regulator of the immune system. What we haven’t understood, until recently, is exactly how the brain senses and modulates immune responses. Nilo Therapeutics is building on pioneering research from the Charles Zuker lab at Columbia University documenting the specific messenger molecules and neural circuits involved in promoting and suppressing inflammation. The company plans to develop drugs that target these circuits in order to manage immune disorders such as toxic shock, cytokine storms, and rheumatoid arthritis and other autoimmune diseases.
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