Unlearn Raises $50 Million Series C to Optimize Clinical Research With AI-Powered Digital Twin Technology

SAN FRANCISCO – (BUSINESS WIRE) – Unlearn®, an AI company creating digital twins of clinical trial partic­i­pants that enable smaller, faster studies, today announced a $50M Series C round led by Altimeter Capital, joined by returning investors Radical Ventures, Wittington Ventures, Mubadala Capital, Epic Ventures, and Necessary Venture Capital. This round of funding was secured to propel the company’s mission to advance AI to eliminate trial and error in medicine by investing in its people, data, engineering capa­bil­i­ties, and longer-term R&D initiatives

Founded in 2017 as an AI research company, Unlearn has always been at the forefront of developing innovative AI-based solutions for clinical trials. Now, seven years later, with over $130M raised, Unlearn’s technology addresses key clinical research challenges, such as long timelines, slow enrollment, and patients’ reluctance to participate over potentially receiving a placebo.

Unlearn’s AI models generate an individual digital twin for every trial participant before they are randomized into the exper­i­mental or control arm. The participant’s digital twin forecasts their health outcomes under placebo, regardless of their actual assignment. Digital twins enable TwinRCTs,^TM highly powered clinical trials with smaller control groups, allowing more patients to receive exper­i­mental treatment. TwinRCTs reduce the time it takes to bring new drugs and therapies to market, ultimately paving the way for improved health outcomes for all.

“Phar­ma­ceu­tical companies are spending over $100 billion dollars a year on clinical research, yet the industry remains skeptical about new technology that has the power to truly transform research,” said Charles Fisher, Ph.D., founder and CEO of Unlearn. ​“Breaking down these barriers and proving the value of digital twin technology continues to be a main driver for us at Unlearn. And, this round of financing will allow us to not only grow our team but also expand our capa­bil­i­ties into more therapeutic areas to build awareness and prove the value.”

Over the last decade, the clinical research industry has seen the intro­duc­tion of advanced solutions to solve its most pressing problems – lack of diversity, years-long timelines from discovery to development, and increasing costs. However, working within regulatory constraints continues to create obstacles and limit progress. Under­standing this, Unlearn has partnered with regulatory experts since its founding and now has a qual­i­fi­ca­tion from the European Medicines Agency for use as the primary analysis in phase 2 and 3 clinical trials with continuous outcomes as well as agreement from the U.S. Food and Drug Admin­is­tra­tion that the methodology does not deviate from current guidance.

“Unlearn is introducing powerful AI models to help make clinical research more streamlined and efficient,” said Pauline Yang, Partner at Altimeter Capital. ​“We’re excited to be a part of their journey to seek to reduce the number of partic­i­pants needed for research, ultimately with hopes of reducing costs and improving outcomes for partners in the pharmaceutical industry.”

“Unlearn has built one of the most original and impactful appli­ca­tions of AI in the market today,” said Rob Toews, Partner at Radical Ventures. ​“The company’s platform is trans­forming clinical trials, using cutting-edge AI to help bring life-changing ther­a­peu­tics to patients sooner.”

With this round of financing, Altimeter joins existing investors included in the round — Radical Ventures, Wittington Ventures, Mubadala Capital, Epic Ventures, Necessary Venture Capital — as well as Insight Partners, 8VC, DCVC, and DCVC Bio.

Unlearn partners with pharma sponsors, biotech companies, and academic insti­tu­tions to streamline and optimize clinical trials, enabling researchers to assess the safety and efficacy of new treatments more quickly and accurately. To learn more about Unlearn’s novel digital technology, visit www.unlearn.ai.

About Unlearn

Unlearn is a San Francisco-based technology company advancing AI to eliminate trial and error in medicine. Unlearn’s technology powers the clinical trials of leading global phar­ma­ceu­tical companies, helping them to reach full enrollment faster and bring new treatments to patients sooner. Their methods using partic­i­pants’ digital twins are qualified by the European Medicines Agency and align with current FDA guidance. For more information, please visit https://www.unlearn.ai or follow @UnlearnAI on X and @unlearn-ai on LinkedIn.